Gemin 2 (GEMIN2) (NM_003616) Human Tagged ORF Clone Lentiviral Particle

SKU RC211219L3V

Lenti ORF particles, GEMIN2 (Myc-DDK tagged) - Human survival of motor neuron protein interacting protein 1 (SIP1), transcript variant alpha, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: Gemin 2
• Synonyms: SIP1; SIP1-delta
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC211219).
• ACCN: NM_003616
• ORF Size: 840 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_003616.2, NP_003607.1
• RefSeq Size: 1368 bp
• RefSeq ORF: 810 bp
• Locus ID: 8487
• UniProt ID: O14893
• Cytogenetics: 14q21.1
• Protein Families: Druggable Genome, Stem cell - Pluripotency
• MW: 31.6 kDa
• Summary: This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011]