JIP1 (MAPK8IP1) (NM_005456) Human Tagged ORF Clone Lentiviral Particle

SKU RC209734L3V

Lenti ORF particles, MAPK8IP1 (Myc-DDK tagged) - Human mitogen-activated protein kinase 8 interacting protein 1 (MAPK8IP1), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: JIP1
• Synonyms: IB1; JIP-1; JIP1; PRKM8IP
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC209734).
• ACCN: NM_005456
• ORF Size: 2133 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_005456.2
• RefSeq Size: 3234 bp
• RefSeq ORF: 2136 bp
• Locus ID: 9479
• UniProt ID: Q9UQF2
• Cytogenetics: 11p11.2
• Protein Families: Druggable Genome
• Protein Pathways: MAPK signaling pathway
• MW: 77.5 kDa
• Summary: This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]