GIRK1 (KCNJ3) (NM_002239) Human Tagged ORF Clone Lentiviral Particle

SKU
RC205322L3V
Lenti ORF particles, KCNJ3 (Myc-DDK tagged) - Human potassium inwardly-rectifying channel, subfamily J, member 3 (KCNJ3), 200ul, >10^7 TU/mL
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    Expression-ready ORF plasmid in lenti backbone

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$1,016.00
3 Weeks*
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Target Symbol GIRK1
Synonyms GIRK1; KGA; KIR3.1
Vector pLenti-C-Myc-DDK-P2A-Puro
Mammalian Cell Selection Puromycin
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC205322).
ACCN NM_002239
ORF Size 1503 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_002239.2
RefSeq Size 4740 bp
RefSeq ORF 1506 bp
Locus ID 3760
UniProt ID P48549
Cytogenetics 2q24.1
Domains IRK
Protein Families Druggable Genome, Ion Channels: Potassium, Transmembrane
MW 56.7 kDa
Summary Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, May 2012]
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.