TLE 1 (TLE1) (NM_005077) Human Tagged ORF Clone Lentiviral Particle

SKU RC204037L3V

Lenti ORF particles, TLE1 (Myc-DDK tagged) - Human transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) (TLE1), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: TLE 1
• Synonyms: ESG; ESG1; GRG1
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC204037).
• ACCN: NM_005077
• ORF Size: 2310 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_005077.3, NP_005068.2
• RefSeq Size: 3283 bp
• RefSeq ORF: 2313 bp
• Locus ID: 7088
• UniProt ID: Q04724
• Cytogenetics: 9q21.32
• Domains: TLE_N, WD40
• Protein Families: Transcription Factors
• MW: 83.2 kDa
• Summary: Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.[UniProtKB/Swiss-Prot Function]