Endothelin 1 (EDN1) (NM_001955) Human Tagged ORF Clone Lentiviral Particle

SKU RC202217L1V

Lenti ORF particles, EDN1 (Myc-DDK tagged) - Human endothelin 1 (EDN1), transcript variant 1, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: Endothelin 1
• Synonyms: ARCND3; ET1; HDLCQ7; PPET1; QME
• Vector: pLenti-C-Myc-DDK
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC202217).
• ACCN: NM_001955
• ORF Size: 636 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_001955.2, NP_001946.2
• RefSeq Size: 2112 bp
• RefSeq ORF: 639 bp
• Locus ID: 1906
• UniProt ID: P05305
• Cytogenetics: 6p24.1
• Domains: END
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Melanogenesis
• MW: 24.4 kDa
• Summary: This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]