PDE6 beta (PDE6B) (NM_000283) Human Tagged ORF Clone Lentiviral Particle

SKU RC200445L3V

Lenti ORF particles, PDE6B (Myc-DDK tagged) - Human phosphodiesterase 6B, cGMP-specific, rod, beta (PDE6B), transcript variant 1, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: PDE6 beta
• Synonyms: CSNB3; CSNBAD2; GMP-PDEbeta; PDEB; rd1; RP40
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC200445).
• ACCN: NM_000283
• ORF Size: 2559 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_000283.2
• RefSeq Size: 3414 bp
• RefSeq ORF: 2565 bp
• Locus ID: 5158
• UniProt ID: P35913
• Cytogenetics: 4p16.3
• Domains: GAF, HDc, PDEase
• Protein Families: Druggable Genome
• MW: 98.2 kDa
• Summary: Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]