Gpr137b (NM_031999) Mouse Tagged ORF Clone Lentiviral Particle

SKU MR206004L3V

Lenti ORF particles, Gpr137b (Myc-DDK-tagged) - Mouse G protein-coupled receptor 137B (Gpr137b), 200ul, >10^7 TU/mL

Product Data

• Type: Mouse Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: Gpr137b
• Synonyms: AI788917; AU016435; AW546472; C80550; C80741; C730041E01; D13Abb1e; Tm7sf1
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR206004).
• ACCN: NM_031999
• ORF Size: 1155 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_031999.2, NP_114388.2
• RefSeq Size: 2996 bp
• RefSeq ORF: 1158 bp
• Locus ID: 83924
• UniProt ID: Q8BNQ3
• Cytogenetics: 13 5.24 cM
• Summary: Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy (By similarity). Acts also as a negative regulator of osteoclast activity (PubMed:31173907). Involved in interleukin-4-induced M2 macrophage polarization (PubMed:30595385).[UniProtKB/Swiss-Prot Function]