Itm2c (NM_022417) Mouse Tagged ORF Clone Lentiviral Particle

SKU MR203562L3V

Lenti ORF particles, Itm2c (Myc-DDK-tagged) - Mouse integral membrane protein 2C (Itm2c), 200ul, >10^7 TU/mL

Product Data

• Type: Mouse Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: Itm2c
• Synonyms: 3110038L02Rik; BRI3; Bricd2c; E25; E25C; ITM3
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR203562).
• ACCN: NM_022417
• ORF Size: 807 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_022417.1, NP_071862.1, NP_071862.2
• RefSeq Size: 2024 bp
• RefSeq ORF: 810 bp
• Locus ID: 64294
• UniProt ID: Q91VK4
• Cytogenetics: 1 C5
• Summary: Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.[UniProtKB/Swiss-Prot Function]