c-Myc (MYC) (NM_002467) Human Untagged Clone

SKU SC112715

MYC (untagged)-Human v-myc myelocytomatosis viral oncogene homolog (avian) (MYC)

Product Data

• Type: Human Untagged Clone
• Target Symbol: c-Myc
• Synonyms: bHLHe39; c-Myc; MRTL; MYCC
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_002467 edited; ATGCCCCTCAACGTTAGCTTCACCAACAGGAACTATGACCTCGACTACGACTCGGTGCAG; CCGTATTTCTACTGCGACGAGGAGGAGAACTTCTACCAGCAGCAGCAGCAGAGCGAGCTG; CAGCCCCCGGCGCCCAGCGAGGATATCTGGAAGAAATTCGAGCTGCTGCCCACCCCGCCC; CTGTCCCCTAGCCGCCGCTCCGGGCTCTGCTCGCCCTCCTACGTTGCGGTCACACCCTTC; TCCCTTCGGGGAGACAACGACGGCGGTGGCGGGAGCTTCTCCACGGCCGACCAGCTGGAG; ATGGTGACCGAGCTGCTGGGAGGAGACATGGTGAACCAGAGTTTCATCTGCGACCCGGAC; GACGAGACCTTCATCAAAAACATCATCATCCAGGACTGTATGTGGAGCGGCTTCTCGGCC; GCCGCCAAGCTCGTCTCAGAGAAGCTGGCCTCCTACCAGGCTGCGCGCAAAGACAGCGGC; AGCCCGAACCCCGCCCGCGGCCACAGCGTCTGCTCCACCTCCAGCTTGTACCTGCAGGAT; CTGAGCGCCGCCGCCTCAGAGTGCATCGACCCCTCGGTGGTCTTCCCCTACCCTCTCAAC; GACAGCAGCTCGCCCAAGTCCTGCGCCTCGCAAGACTCCAGCGCCTTCTCTCCGTCCTCG; GATTCTCTGCTCTCCTCGACGGAGTCCTCCCCGCAGGGCAGCCCCGAGCCCCTGGTGCTC; CATGAGGAGACACCGCCCACCACCAGCAGCGACTCTGAGGAGGAACAAGAAGATGAGGAA; GAAATCGATGTTGTTTCTGTGGAAAAGAGGCAGGCTCCTGGCAAAAGGTCAGAGTCTGGA; TCACCTTCTGCTGGAGGCCACAGCAAACCTCCTCACAGCCCACTGGTCCTCAAGAGGTGC; CACGTCTCCACACATCAGCACAACTACGCAGCGCCTCCCTCCACTCGGAAGGACTATCCT; GCTGCCAAGAGGGTCAAGTTGGACAGTGTCAGAGTCCTGAGACAGATCAGCAACAACCGA; AAATGCACCAGCCCCAGGTCCTCGGACACCGAGGAGAATGTCAAGAGGCGAACACACAAC; GTCTTGGAGCGCCAGAGGAGGAACGAGCTAAAACGGAGCTTTTTTGCCCTGCGTGACCAG; ATCCCGGAGTTGGAAAACAATGAAAAGGCCCCCAAGGTAGTTATCCTTAAAAAAGCCACA; GCATACATCCTGTCCGTCCAAGCAGAGGAGCAAAAGCTCATTTCTGAAGAGGACTTGTTG; CGGAAACGACGAGAACAGTTGAAACACAAACTTGAACAGCTACGGAACTCTTGTGCGTAA;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002467 unedited; TAGATTTCTGTACACGATTCACTATAGGGCGGCCGCGCAATTCGCACGAGGCGGCTAGGG; TGGAAGAGCCGGGCGAGCAGAGCTGCGCTGCGGGCGTCCTGGGAAGGGAGATCCGGAGCG; AATAGGGGGCTTCGCCTCTGGCCCAGCCCTCCCGCTGATCCCCCAGCCAGCGGTCCGCAA; CCCTTGCCGCATCCACGAAACTTTGCCCATAGCAGCGGGCGGGCACTTTGCACTGGAACT; TACAACACCCGAGCAAGGACGCGACTCTCCCGACGCGGGGAGGCTATTCTGCCCATTTGG; GGACACTTCCCCGCCGCTGCCAGGACCCGCTTCTCTGAAAGGCTCTCCTTGCAGCTGCTT; AGACGCTGGATTTTTTTCGGGTAGTGGAAAACCAGCCTCCCGCGACGATGCCCCTCAACG; TTAGCTTCACCAACAGGAACTATGACCTCGACTACGACTCGGTGCAGCCGTATTTCTACT; GCGACGAGGAGGAGAACTTCTACCAGCAGCAGCAGCCAGAGCGAGCTGCAGCCCCCGGCG; CCCAGCGAGGATATCTGGAAGAAATTCGAGCTGCTGCCCACCCCGCCCCTGTCCCCTAGC; CGCCGCTCCGGGCTCTGCTCGCCCTCCTACGTTGCGGTCACACCCTTCTCCCTTCGGGGA; GACAACGACGGCGGTGGCGGGAGCTTCTCCACGGCCGACCAGCTGTAGATGGTGACCGAG; CTGCTGCGAGGAGACATGCTGAACCACAGTTTCATCTGCGACCCGGACGACGAGACCTTC; ATCAAAAACATCATCATCCAGGACTGTATGTGGGAGCGGCTTTTTCGGCGCCGCCAAGCT; CGTCTCAGAGAGCTGGGCCTCTACAGGGCTGAGCGCAAGACAGAGGNAGACCGAACCCGC; CCGCGGGCCCAGNGTCTGCTCCACCTCCACTTGTACTGCAGTATCTGACGCCGCGCTCAC; ATGCAT;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002467 unedited; TACTTTGGACCCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTATATTTGC; CAGTTATTTTATTTTTTCTAAAAACAATAGAAAAAATCAACTTTAAAAAGCAAAATGTAC; TTAAATAAAAAAAATTAGGGTTTATAGTACCTATAATACTAGGTACTATATACTAGGATT; GAAATTCTGTGTAACTGCTATAAACGTTTTNATTAAAGTTNTATTTACATTTAATGGCAA; TATTTACAGAGAAACATTGTGTAAATCTTAAAATTTTTTAAAAACAATTCTTAAATACAA; ATCTGTTAAAGAAAAAAAAAAGATGGTAAGCATAAAAAAGTTCTTTTATGCCCAAAGTCC; AATTTGAGGCAGTTTACATTATGGCTAAATCTTTCAGTCTCAAGACTCAGCCAAGGTTGT; GAGGTTGCATTTGATCATGCATTTGAAACAAGTTCATAGGTGATTGCTCANGACATTTCT; GTTAGAAGGAAATCGTTTCCTTACTTTTCCTTACGCACAAAGAGTCCGTAGCTGTTCAAG; TTTGTGTTTCAACTGTTCTCGTCGTTTCCGCAACAAGTCCTCTTCAGAAATGAGCTTTTG; CTCCTCTGCTTGNACGGACAGGATGTATGCTGTGGNCTTTTTAANGGATAACTACCTTNG; GGGGNCCCTTTCATGNTTTCCAACTNCCGGATCTGGTCACGCAGGGCAAAAAAGCTNCGT; TTTAACTCGTTTCTTCTCTGGCGCTNCAAGACGTTGGGTGTTCGCCTCTTGACATTCTCC; TCGGTGTCCGAAGACCTGGGGNCTGTGCATTTTCCGGTGGTGCTGATCTGCTTAAGACTT; TGACACTGTCAACTTGACCCTTTTGCAACAGAAAGTCCTTCGAATGAAGGGAGCCCTGCC; TAATTGCCTAATGTTGGAAACTGGGCACTCTTGAGAACAAGGGCCTTAAGAGGTTTTCTG; GGCCTCACCAAAAGGAACCAACTTTGCCCTTTGCCAAAC;
• Restriction Sites: ECoRI-NOT
• ACCN: NM_002467
• Insert Size: 1365 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_002467.3, NP_002458.2
• RefSeq Size: 2377 bp
• RefSeq ORF: 1365 bp
• Locus ID: 4609
• UniProt ID: P01106
• Cytogenetics: 8q24.21
• Domains: HLH, Myc-LZ, Myc_N_term
• Protein Families: Druggable Genome, Embryonic stem cells, Induced pluripotent stem cells, Stem cell - Pluripotency, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - TGFb/BMP signaling pathway, Stem cell relevant signaling - Wnt Signaling pathway, Transcription Factors
• Protein Pathways: Acute myeloid leukemia, Bladder cancer, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Jak-STAT signaling pathway, MAPK signaling pathway, Pathways in cancer, Small cell lung cancer, TGF-beta signaling pathway, Thyroid cancer, Wnt signaling pathway
• Summary: This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]