Samhd1 (NM_018851) Mouse Tagged ORF Clone
CAT#: MR218369
- TrueORF®
Samhd1 (Myc-DDK-tagged) - Mouse SAM domain and HD domain, 1 (Samhd1), transcript variant 1
ORF Plasmid: tGFP
Lentiviral Particles: DDK w/ Puro mGFP w/ Puro
"NM_018851" in other vectors (5)
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Specifications
Product Data | |
Type | Mouse Tagged ORF Clone |
Tag | Myc-DDK |
Symbol | Samhd1 |
Synonyms | E330031J07Rik; Mg11 |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>MR218369 representing NM_018851
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGACTCACTTTTGGGGTGTGGTGTCAGTGCGGCTGCGCGCGAGCCGGTGCCGCGGTACTTAACTTCGC AGCCCCGGGTGTCGGAGGTAGCCATGCAGAGCGCACCCTTGGAGCAGCCAGCTAAGCGACCCCGCTGCGA TGGCAGCCCAAGGACGCCACCGAGCACTCCTCCTGCAACAGCTAATCTGTCTGCAGACGACGACTTCCAA AACACCGACCTCCGAACCTGGGAACCGGAGGACGTGTGCTCCTTCTTAGAGAATCGTGGTTTCCGAGAGA AGAAAGTGCTGGACATCTTCAGAGACAATAAAATCGCCGGCTCGTTTCTGCCCTTTTTGGATGAGGATCG TCTGGAAGATCTGGGAGTAAGTTCCTTGGAGGAGAGGAAGAAGATGATAGAATGTATCCAGCAGCTGAGT CAGTCTCGGATTGATCTAATGAAGGTATTTAATGATCCCATTCATGGCCACATTGAGTTCCACCCTCTCC TTATCAGAATCATCGACACACCTCAGTTCCAGCGACTTCGCTATATCAAGCAGCTGGGGGGCGGCTACTA TGTTTTCCCTGGAGCGTCCCACAATCGCTTCGAACACAGTCTCGGAGTGGGGTACCTAGCAGGCTGCCTG GTGCGAGCACTTGCCGAAAAACAGCCAGAGCTACAGATCAGTGAGCGAGATATACTCTGTGTTCAGATTG CGGGGCTCTGCCACGACCTAGGTCATGGGCCATTTTCTCATATGTTTGATGGAAGGTTTATCCCACGGGC TCGCCCAGAGAAAAAGTGGAAGCACGAACAGGGCTCCATTGAGATGTTTGAGCATCTGGTCAATTCTAAT GAACTCAAACTTGTCATGAAGAACTATGGTCTCGTCCCTGAAGAAGACATTACCTTTATCAAGGAACAAA TTATGGGACCACCTATAACACCAGTCAAAGATTCCTTGTGGCCGTATAAAGGCCGCCCTGCCACGAAGAG CTTCCTTTACGAGATAGTGTCTAACAAGAGGAATGGCATCGACGTAGACAAATGGGATTATTTTGCCAGA GACTGTCACCATCTTGGAATCCAAAATAATTTTGATTACAAGCGCTTCATTAAGTTTGCCCGTATCTGTG AAGTGGAGTACAAGGTCAAGGAGGACAAGACCTACATCCGTAAGGTGAAGCACATTTGTTCGAGAGAAAA GGAGGTTGGAAATCTGTATGACATGTTCCACACTCGCAACTGCTTACACCGAAGAGCTTACCAACACAAG ATCAGCAACCTCATCGACATAATGATTACAGATGCCTTCCTCAAAGCAGACCCCTACGTGGAGATTACAG GGACTGCCGGGAAGAAGTTCCGCATTTCCACAGCCATTGATGACATGGAAGCCTTCACTAAGTTGACGGA TAACATTTTTCTGGAGGTTTTACACTCTACTGATCCACAGTTGTCTGAGGCCCAAAGTATTTTAAGGAAC ATTGAATGCCGCAATCTATACAAGTATTTGGGTGAGACCCAGCCAAAGCGTGAGAAGATTAGGAAGGAAG AATATGAACGGCTTCCCCAAGAAGTTGCTAAAGCCAAACCTGAAAAAGCCCCGGATGTTGAACTGAAGGC CGAAGATTTCATAGTTGATGTTATCAATGTGGATTATGGGATGGAAGACAAGAATCCAATCGATCGTGTT CACTTCTATTGTAAGAGCAACAGCAAGCAAGCGGTCAGGATCAATAAAGAGCAGGTGTCACAACTGCTGC CAGAGAAATTTGCAGAGCAGCTCATTCGGGTGTACTGTAAGAAGAAAGACGGGAAGAGCCTGGACGCCGC CGGGAAGCACTTTGTTCAGTGGTGTGCGCTCAGGGACTTCACCAAGCCACAGGATGGTGACATTATAGCT CCACTCATAACACCTCTGAAATGGAATAATAAGACTTCATCTTGCCTCCAAGAAGTATCCAAAGTAAAAA CATGTCTAAAATTT ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >MR218369 representing NM_018851
Red=Cloning site Green=Tags(s) MDSLLGCGVSAAAREPVPRYLTSQPRVSEVAMQSAPLEQPAKRPRCDGSPRTPPSTPPATANLSADDDFQ NTDLRTWEPEDVCSFLENRGFREKKVLDIFRDNKIAGSFLPFLDEDRLEDLGVSSLEERKKMIECIQQLS QSRIDLMKVFNDPIHGHIEFHPLLIRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCL VRALAEKQPELQISERDILCVQIAGLCHDLGHGPFSHMFDGRFIPRARPEKKWKHEQGSIEMFEHLVNSN ELKLVMKNYGLVPEEDITFIKEQIMGPPITPVKDSLWPYKGRPATKSFLYEIVSNKRNGIDVDKWDYFAR DCHHLGIQNNFDYKRFIKFARICEVEYKVKEDKTYIRKVKHICSREKEVGNLYDMFHTRNCLHRRAYQHK ISNLIDIMITDAFLKADPYVEITGTAGKKFRISTAIDDMEAFTKLTDNIFLEVLHSTDPQLSEAQSILRN IECRNLYKYLGETQPKREKIRKEEYERLPQEVAKAKPEKAPDVELKAEDFIVDVINVDYGMEDKNPIDRV HFYCKSNSKQAVRINKEQVSQLLPEKFAEQLIRVYCKKKDGKSLDAAGKHFVQWCALRDFTKPQDGDIIA PLITPLKWNNKTSSCLQEVSKVKTCLKF TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Restriction Sites | SgfI-MluI Cloning Scheme for this gene Plasmid Map |
ACCN | NM_018851 |
ORF Size | 1974 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_018851.3, NP_061339.3 |
RefSeq Size | 3887 bp |
RefSeq ORF | 1977 bp |
Locus ID | 56045 |
UniProt ID | Q60710 |
Cytogenetics | 2 H1 |
MW | 76.3 kDa |
Gene Summary | Isoform 1: Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (By similarity). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells (PubMed:23972988, PubMed:23872947, PubMed:26667483, PubMed:29379009). Likewise, suppresses LINE-1 retrotransposon activity (PubMed:26667483). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (By similarity). Phosphorylation at Thr-634 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (By similarity). Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication (By similarity). Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation (By similarity). Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (By similarity). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (PubMed:29669924).[UniProtKB/Swiss-Prot Function] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
MC218733 | Samhd1 (untagged) - Mouse SAM domain and HD domain, 1 (Samhd1), transcript variant 1, (10ug) |
USD 675.00 |
|
MG209564 | Samhd1 (tGFP-tagged) - Mouse SAM domain and HD domain, 1 (Samhd1) |
USD 785.00 |
|
MG218369 | Samhd1 (tGFP-tagged) - Mouse SAM domain and HD domain 1 (Samhd1) transcript variant 1, (10ug) |
USD 874.00 |
|
MR218369L3 | Lenti ORF clone of Samhd1 (Myc-DDK-tagged) - Mouse SAM domain and HD domain, 1 (Samhd1), transcript variant 1 |
USD 974.00 |
|
MR218369L4 | Lenti ORF clone of Samhd1 (mGFP-tagged) - Mouse SAM domain and HD domain, 1 (Samhd1), transcript variant 1 |
USD 974.00 |
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