LXR alpha (NR1H3) Human shRNA Plasmid Kit (Locus ID 10062)

SKU TL320630

NR1H3 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 10062
• Synonyms: LXR-a; LXRA; RLD-1
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: NR1H3 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 10062). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_001130101, NM_001130102, NM_001251934, NM_001251935, NM_005693, NM_005693.1, NM_005693.3, NM_001130101.1, NM_001130101.2, NM_001130102.1, NM_001130102.2, NM_001251934.1, NM_001251935.1, BC008819, BC041172, BM835230, NM_001363595, NM_005693.4, NM_001130102.3, NM_001130101.3
• UniProt ID: Q13133
• Summary: The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient