Glucocorticoid Receptor (NR3C1) Human shRNA Plasmid Kit (Locus ID 2908)

SKU TL320374

NR3C1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 2908
• Synonyms: GCCR; GCR; GCRST; GR; GRL
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: NR3C1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 2908). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_000176, NM_001018074, NM_001018075, NM_001018076, NM_001018077, NM_001020825, NM_001024094, NM_001204258, NM_001204259, NM_001204260, NM_001204261, NM_001204262, NM_001204263, NM_001204264, NM_001204265, NM_001018074.1, NM_000176.1, NM_000176.2, NM_001018076.1, NM_001020825.1, NM_001024094.1, NM_001018075.1, NM_001018077.1, NM_001204264.1, NM_001204263.1, NM_001204262.1, NM_001204265.1, NM_001204261.1, NM_001204260.1, NM_001204259.1, NM_001204258.1, BC015610, BC015610.2, NM_001364182, NM_001364184, NR_157096, NM_001364180, NM_001364181, NM_001364183, NM_001364185, NM_001204265.2, NM_001204258.2, NM_001204261.2, NM_001204263.2, NM_001204259.2, NM_001204262.2, NM_001204260.2, NM_001024094.2, NM_001204264.2, NM_001020825.2, NM_001018076.2, NM_000176.3
• UniProt ID: P04150
• Summary: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient