ATM Human shRNA Plasmid Kit (Locus ID 472)

SKU TL320267

ATM - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 472
• Synonyms: AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: ATM - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 472). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: BC007023, NM_000051, NM_138292, NM_138293, NM_001351834, NM_001351835, NM_001351836, NM_138292.1, NM_138292.2, NM_138292.3, NM_000051.3, BC022306, BC022307, BC061584, BC137169, BC152385, BC152389, NM_000051.4
• UniProt ID: Q13315
• Summary: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient