DDX3 (DDX3X) Human shRNA Plasmid Kit (Locus ID 1654)

SKU TL316514

DDX3X - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 1654
• Synonyms: CAP-Rf; DBX; DDX3; DDX14; HLP2; MRX102; MRXSSB
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: DDX3X - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 1654). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_001193416, NM_001193417, NM_001356, NM_024005, NR_126093, NR_126094, NM_001356.1, NM_001356.2, NM_001356.3, NM_001356.4, NM_001193416.1, NM_001193416.2, NM_001193417.1, NM_001193417.2, BC011819, BC011819.2, BC007668, BC055083, BM454841, BM833870, NM_001363819, NM_001193417.3, NM_001193416.3, NM_001356.5
• UniProt ID: O00571
• Summary: The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient