BLM Human shRNA Plasmid Kit (Locus ID 641)

SKU TL314471

BLM - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 641
• Synonyms: BS; MGRISCE1; RECQ2; RECQL2; RECQL3
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: BLM - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 641). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_000057, NM_001287246, NM_001287247, NM_001287248, NM_000057.1, NM_000057.2, NM_000057.3, NM_001287248.1, NM_001287247.1, NM_001287246.1, BC034480, BC062697, BC093622, BC101567, BC107423, BC115028, BC115029, BC115030, BC115031, BC115032, BC143280, BC143288, NM_001287248.2, NM_001287246.2, NM_000057.4, NM_001287247.2
• UniProt ID: P54132
• Summary: The Bloom syndrome is an autosomal recessive disorder characterized by growth deficiency, microcephaly and immunodeficiency among others. It is caused by homozygous or compound heterozygous mutation in the gene encoding DNA helicase RecQ protein on chromosome 15q26. This Bloom-associated helicase unwinds a variety of DNA substrates including Holliday junction, and is involved in several pathways contributing to the maintenance of genome stability. Identification of pathogenic Bloom variants is required for heterozygote testing in at-risk families. [provided by RefSeq, May 2020]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient