Leptin Receptor (LEPR) Human shRNA Plasmid Kit (Locus ID 3953)

SKU TL311760

LEPR - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 3953
• Synonyms: CD295; LEP-R; LEPRD; OB-R; OBR
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: LEPR - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 3953). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_001003679, NM_001003680, NM_001198687, NM_001198688, NM_001198689, NM_002303, NM_001003680.1, NM_001003680.2, NM_001003680.3, NM_001003679.1, NM_001003679.2, NM_001003679.3, NM_002303.1, NM_002303.2, NM_002303.3, NM_002303.4, NM_002303.5, NM_001198688.1, NM_001198689.1, NM_001198687.1, BC031086, BC035120, BC131779, BC160009, NM_001198687.2, NM_002303.6
• UniProt ID: P48357
• Summary: The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient