Caspase 3 (CASP3) Human shRNA Plasmid Kit (Locus ID 836)

SKU TL305638

CASP3 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 836
• Synonyms: CPP32; CPP32B; SCA-1
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: CASP3 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 836). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_004346, NM_032991, NM_001354777, NM_001354778, NM_001354779, NM_001354780, NM_001354781, NM_001354782, NM_001354783, NM_001354784, NM_032991.1, NM_032991.2, NM_004346.1, NM_004346.2, NM_004346.3, BC016926, BC016926.2, NM_004346.4
• UniProt ID: P42574
• Summary: The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient