Cathepsin B (CTSB) Human shRNA Plasmid Kit (Locus ID 1508)

SKU TL305176

CTSB - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 1508
• Synonyms: APPS; CPSB; RECEUP
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: CTSB - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 1508). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_001317237, NM_001908, NM_147780, NM_147781, NM_147782, NM_147783, NM_147783.1, NM_147783.2, NM_147783.3, NM_001908.1, NM_001908.2, NM_001908.3, NM_001908.4, NM_147782.1, NM_147782.2, NM_147782.3, NM_147780.1, NM_147780.2, NM_147780.3, NM_147781.1, NM_147781.2, NM_147781.3, BC095408, BC095408.1, BC010240, BM008741, NM_147783.4, NM_147780.4, NM_147781.4, NM_147782.4, NM_001908.5
• UniProt ID: P07858
• Summary: This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Both Cathepsin B and Cathepsin L are involved in the cleavage of the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon its entry to the human host cell. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Sep 2020]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient