Prion protein PrP (PRNP) Human shRNA Plasmid Kit (Locus ID 5621)

SKU TL302273

PRNP - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 5621
• Synonyms: AltPrP; ASCR; CD230; CJD; GSS; KURU; p27-30; PRIP; PrP; PrP27-30; PrP33-35C; PrPc
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: PRNP - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 5621). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_000311, NM_001080121, NM_001080122, NM_001080123, NM_001271561, NM_183079, NM_001080123.1, NM_001080123.2, NM_000311.1, NM_000311.2, NM_000311.3, NM_000311.4, NM_183079.1, NM_183079.2, NM_183079.3, NM_001080122.1, NM_001080122.2, NM_001080121.1, NM_001080121.2, NM_001271561.1, NM_001271561.2, BC012844, BC012844.1, BC022532, BC022532.1, BC016809, NM_001271561.3, NM_183079.4, NM_001080122.3, NM_001080121.3, NM_001080123.3, NM_000311.5
• UniProt ID: P04156
• Summary: The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient