RAD18 Human shRNA Plasmid Kit (Locus ID 56852)

SKU
TL302132
RAD18 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
In Stock*
Specifications
Product Data
Locus ID 56852
Synonyms RNF73
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Format Lentiviral plasmids
Components RAD18 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 56852). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_020165, NM_020165.1, NM_020165.2, NM_020165.3, BC001302, BC001302.1
UniProt ID Q9NS91
Summary The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
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