NCX1 (SLC8A1) Human shRNA Plasmid Kit (Locus ID 6546)

SKU TL301534

SLC8A1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 6546
• Synonyms: NCX1
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: SLC8A1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 6546). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_001112800, NM_001112801, NM_001112802, NM_001252624, NM_021097, NM_001351483, NM_001351484, NM_001351485, NM_001351486, NM_001351487, NM_001351488, NM_001351489, NM_001351490, NM_001351491, NM_001351492, NM_001351493, NM_001351494, NM_021097.1, NM_021097.2, NM_001112802.1, NM_001112801.1, NM_001112800.1, NM_001252624.1, BC098285, BC098308, BC098345, BC156359, BC172488, NM_001112800.2, NM_021097.4, NM_001112802.2, NM_001112801.3, NM_001252624.2
• UniProt ID: P32418
• Summary: In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient