CD44 Human Recombinant Protein

SKU TP727932

Recombinant Human CD44/MIC4 (C-Fc)

Product Data

• Species: Human
• Protein Source: Human
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Gln21-Pro220
• Tag: C-Fc
• Buffer: Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Note: Recombinant Human CD44 is produced by our Mammalian expression system and the target gene encoding Gln21-Pro220 is expressed with a Fc tag at the C-terminus.
• Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Stability: 12 months from date of despatch
• Shipping: Ambient

Reference Data

• Locus ID: 960
• UniProt ID: P16070
• Synonyms: CD44 Antigen; CDw44; Epican; Extracellular Matrix Receptor III; ECMR-III; GP90 Lymphocyte Homing/Adhesion Receptor; HUTCH-I; Heparan Sulfate Proteoglycan; Hermes Antigen; Hyaluronate Receptor; Phagocytic Glycoprotein 1; PGP-1; Phagocytic Glycoprotein I; PGP-I; CD44; LHR; MDU2; MDU3; MIC4
• Summary: CD44 is a cell-surface receptor for hyaluronic acid and also interacts with other ligands, such as osteopontin, collagens, and matrix metalloproteinases. A large number of CD44 isoforms can be generated by the insertion of different combinations of at least nine exons. Increased CD44 antigen is associated with relapses in non-small cell lung cancers. Furthermore, an increasing quantity of evidence suggests that CD44 has various functions related to inflammatory disease. CD44 deficiency induces severe liver injury. CD44-hyaluronate mediates in lymphocyte T and monocyte adhesion to the endothelium, stimulates proinflammatory cytokine release from macrophages and participates in dedifferentiation phenotype of smooth muscle cells from contractile state to synthetic one.
• Protein Families: Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Transmembrane
• Protein Pathways: ECM-receptor interaction, Hematopoietic cell lineage