IL10 (NM_000572) Human Recombinant Protein

CAT#: TP723723

Reviews ()
Write a review

Purified recombinant protein of Human interleukin 10 (IL10)

 Product Datasheet for 'TP723723'

  View other "IL10" proteins (8)

USD 265.00

5 Days

    • 10 ug

Product images


Product Data
Description Purified recombinant protein of Human interleukin 10 (IL10)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence Human IL-10, the region of Ser19-Asn178, from gene Accession# NM_000572
Tag Tag Free
Predicted MW 18.6 kDa
Concentration Protein formulated and vialed at >50 ug/mL in specified buffer
Purity >95%, as determined by Coomassie stained SDS-PAGE.
Buffer 1 x PBS
Bioactivity The ED50 is 0.1 - 0.3 ng/ml corresponding to a specific activity of 3.3 - 10 x 10^6 units/mg, determined by the dose dependent inhibition of IFNg production by PHA activated PBMC.
Endotoxin Less than 0.01 ng per µg protein as determined by the LAL method.
Reference Data
RefSeq NP_000563
Locus ID 3586
Refseq Size 1629
Cytogenetics 1q32.1
Refseq ORF 534
Synonyms CSIF; GVHDS; IL-10; IL10A; TGIF
Summary The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2011]
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
Protein Pathways Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway


Other Versions

Other products for "IL10"
Frequently bought together (1)
lL-10 Rat monoclonal antibody, clone OTI12G8
    • 50 ug

USD 360.00

Customer Reviews 
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
BOGO Free lysates
68 Mouse Clones