IL10 (NM_000572) Human Recombinant Protein

CAT#: TP723714

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Purified recombinant protein of Human interleukin 10 (IL10)

 Product Datasheet for 'TP723714'

  View other "IL10" proteins (8)

USD 255.00

5 Days

    • 10 ug

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Product Data
Description Purified recombinant protein of Human interleukin 10 (IL10)
Species Human
Expression Host E. coli
Tag Tag Free
Predicted MW 18.6 kDa
Concentration Protein formulated and vialed at >50 ug/mL in specified buffer
Purity Purity is >98%, as determined by Coomassie stained SDS-PAGE.
Buffer 10mM NaH2PO4, 150mM NaCl, pH7.2
Bioactivity The ED50 is 0.8 - 1.5 ng/ml corresponding to a specific activity of 1.25 - 0.66 x 10^6 units/mg, determined by the dose dependent stimulation of MC/9 cell proliferation.
Endotoxin Less than 0.01 ng per ug protein as determined by the LAL method
Reference Data
RefSeq NP_000563
Locus ID 3586
Refseq Size 1629
Cytogenetics 1q32.1
Refseq ORF 534
Synonyms CSIF; GVHDS; IL-10; IL10A; TGIF
Summary The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2011]
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
Protein Pathways Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway


Other Versions

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68 Mouse Clones