CD38 Human Recombinant Protein

CAT#: TP721243

Biotinylated Human CD38 Protein (C-His-Avi)

Product Images

Biotinylated Human CD38 protein (C-His-Avi) on SDS-PAGE under reducing condition P(+) and non-reducing condition P(-). The purity of this protein appears to be greater than 95% based on Coomassie-blue staining.

Specifications

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Val43-Ile300
• Tag: C-His-Avi
• Predicted MW: The protein has a predicted molecular weight of 33 kDa and migrates at approximately 35-45 kDa on SDS-PAGE with DTT-reduced conditions.
• Concentration: 25µg size is bottled at 0.2mg/mL concentration. 100 µg size is bottled at lot specific concentration.
• Purity: >90%
• Conjugation: Biotin
• Presentation: Purified
• Buffer: 1xPBS buffer, pH7.4
• Bioactivity: Positive
  
  The definition of the active protein (purified and biotinylated) is defined as the protein that can bind to its biological receptor/ligand. For conjugated protein, it is defined with its function to bind to the ScFv of the active CAR-transfected cells in flow cytometry test.
• Preparation: Affinity Ni-NTA
• Applications: ELISA
• Storage: An unopened vial can be stored at 4°C for 2 weeks or at -20°C and below for six months. This stock solution should be aliquoted and stored at ≤ -70°C to minimize the freeze/thaw cycles.
• Stability: 6 Months

Reference Data

• RefSeq: NP_001766.2
• Locus ID: 952
• UniProt ID: P28907
• Summary: Cluster of differentiation 38 (CD38) is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed in many immune cells including B cells, T lymphocytes, and NK cells. CD38 is expressed at high levels in some organs like pancreas, liver, kidney, brain, testis, ovary. CD38 can function as either a cell surface receptor or as an enzyme. As the receptor, CD38 can activate T cells and promote cytokine production. As the multifunctional enzyme, CD38 can regulating calcium mediated signal transduction through the production of cyclic ADP-ribose (cADPR) in many types of cells. Clinically, elevated CD38 expression is prognostic marker in chronic lymphocytic leukemia.