MAP2K1IP1 (LAMTOR3) (NM_021970) Human Recombinant Protein

SKU TP720523

Recombinant protein of human MAPK scaffold protein 1 (MAPKSP1), transcript variant 1

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Met1-Val124
• Tag: N-His
• Predicted MW: 15.8 kDa
• Concentration: lot specific
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 100mM NaCl, 5mM DTT, 30% Glycerol, pH 8.0.
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Storage: Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
• Stability: Stable for at least 3 months from date of receipt under proper storage and handling conditions.
• Shipping: Dry Ice

Reference Data

• RefSeq: NP_068805
• Locus ID: 8649
• UniProt ID: Q9UHA4
• Cytogenetics: 4q23
• Synonyms: MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633; Ragulator3
• Summary: This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]
• Protein Families: Druggable Genome
• Protein Pathways: MAPK signaling pathway