Fgfr1 (NM_010206) Mouse Recombinant Protein
SKU
TP525708
Purified recombinant protein of Mouse fibroblast growth factor receptor 1 (Fgfr1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
$1,020.00
4 Weeks*
Specifications
| Product Data | |
| Species | Mouse |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-MYC/DDK |
| Predicted MW | 92.4 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C after receiving vials. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_034336 |
| Locus ID | 14182 |
| UniProt ID | P16092 |
| Cytogenetics | 8 14.12 cM |
| RefSeq Size | 5008 |
| RefSeq ORF | 2466 |
| Synonyms | AW208770; bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG; Flt-2; Hspy; MFR |
| Summary | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity).UniProtKB/Swiss-Prot Function |
| Protein Categories | Cancer: Gynecologic, CD Markers, Cytokines, Endocrine and metabolic diseases, Enzyme: Kinases, Growth Factors, Intracellular Proteins, Membrane Proteins |
Reviews
Documents
| FAQs |
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Resources
| Recombinant Protein Resources |
Citations
Nonamplified FGFR1 is a growth driver in malignant pleural mesothelioma
Marek, Hinz, von Mässenhausen et al
Mol Cancer Res (2014) 12 (10), 1460-9 DOI: 10.1158/1541-7786.MCR-14-0038
Marek, Hinz, von Mässenhausen et al
Mol Cancer Res (2014) 12 (10), 1460-9 DOI: 10.1158/1541-7786.MCR-14-0038
AI Summary: In this study, OriGene products—specifically the FGFR1 shRNA lentiviral particles—were used to achieve RNAi-mediated silencing of FGFR1, helping to demonstrate the requirement of FGFR1 for the growth of certain malignant pleural mesothelioma cell lines.
FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies
Wynes, Hinz, Gao et al
Clin Cancer Res (2014) 20 (12), 3299-309 DOI: 10.1158/1078-0432.CCR-13-3060
Wynes, Hinz, Gao et al
Clin Cancer Res (2014) 20 (12), 3299-309 DOI: 10.1158/1078-0432.CCR-13-3060
AI Summary: OriGene products contributed to this study by providing the FGFR1 cDNA clone (RC207373) and FGFR1 antibody (TA502048), which were used to assess FGFR1 mRNA and protein expression, respectively, enabling the authors to evaluate their predictive value for FGFR TKI sensitivity in lung cancer.
Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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