MCM7 (NM_005916) Human Recombinant Protein
SKU
TP313809L
Recombinant protein of human minichromosome maintenance complex component 7 (MCM7), transcript variant 1, 1 mg
$7,820.00
6 Weeks*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 81.1 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_005907 |
| Locus ID | 4176 |
| UniProt ID | P33993 |
| Cytogenetics | 7q22.1 |
| RefSeq Size | 2821 |
| RefSeq ORF | 2157 |
| Synonyms | CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146; PPP1R104 |
| Summary | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. provided by RefSeq, Jul 2008 |
| Protein Categories | Growth Factors, Intracellular Proteins |
| Protein Families | Transcription Factors |
| Protein Pathways | Cell cycle, DNA replication |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Citations
Replication stress induced by CCNE1 overexpression creates a dependency on XRCC2 at the replication fork
Doberstein, Karst, Kroeger et al
bioRxiv (2018)
Doberstein, Karst, Kroeger et al
bioRxiv (2018)
Snippet: Page 1. 1 Replication stress induced by CCNE1 overexpression creates a dependency on XRCC2 at the replication fork Kai Doberstein1, Alison Karst2, Paul T Kroeger Jr.1, Ronny Drapkin1,3,4,* Affiliations 1 Penn Ovarian Cancer View as HTML;For the GST pulldown assays, 0.03 nmol of either GST or GST-XRCC2 (Abcam) fusion protein was incubated for 2 h at 4°C with 0.03 nmol of full length recombinant MCM7 (Origene) in a final volume of 0.1 ml binding buffer (50 mM Tris-HCl pH 7.4, 150 mM NaCl, 10 mM MgCl2). …
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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