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TACC3 (NM_006342) Human Recombinant Protein

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SKU
TP310754
Recombinant protein of human transforming, acidic coiled-coil containing protein 3 (TACC3), 20 µg
Size:
20 ug 1 mg 100 ug
  $867.00
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Frequently Bought Together (1)

TA592569 DDK Rabbit monoclonal antibody, recognizing both N- and C-terminal tags
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Other products for "TACC3 or NM_006342"

Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
>RC210754 representing NM_006342
Red=Cloning site Green=Tags(s)

MSLQVLNDKNVSNEKNTENCDFLFSPPEVTGRSSVLRVSQKENVPPKNLAKAMKVTFQTPLRDPQTHRIL
SPSMASKLEAPFTQDDTLGLENSHPVWTQKENQQLIKEVDAKTTHGILQKPVEADTDLLGDASPAFGSGS
SSKSGPGALADLDCSSSSQSPGSSENQMVSPGKVSGSPEQAVEENLSSYSLDRRVTPASETLEDPCRTES
QHKAETPHGAEEECKAETPHGAEEECRHGGVCAPAAVATSPPGAIPKEACGGAPLQGLPGEALGCPAGVG
TPVPADGTQTLTCAHTSAPESTAPTNHLVAGRAMTLSPQEEVAAGQMASSSRSGPVKLEFDVSDGATSKR
APPPRRLGERSGLKPPLRKAAVRQQKAPQEVEEDDGRSGAGEDPPMPASRGSYHLDWDKMDDPNFIPFGG
DTKSGCSEAQPPESPETRLGQPAAEQLHAGPATEEPGPCLSQQLHSASAEDTPVVQLAAETPTAESKERA
LNSASTSLPTSCPGSEPVPTHQQGQPALELKEESFRDPAEVLGTGAEVDYLEQFGTSSFKESALRKQSLY
LKFDPLLRDSPGRPVPVATETSSMHGANETPSGRPREAKLVEFDFLGALDIPVPGPPPGVPAPGGPPLST
GPIVDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAE
IQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAH
AEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEKI

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag C-Myc/DDK
Predicted MW 90.2 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_006333
Locus ID 10460
UniProt ID Q9Y6A5
Cytogenetics 4p16.3
RefSeq Size 2788
RefSeq ORF 2514
Synonyms ERIC-1; ERIC1; maskin; Tacc4
Summary This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. provided by RefSeq, Nov 2011
Protein Categories Intracellular Proteins
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Other "TACC3" proteins (3)
SKU Description Size Price
PH310754 TACC3 MS Standard C13 and N15-labeled recombinant protein (NP_006333) 10 ug
$3,360.00
LC416710 Lyophilized TACC3 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY416710 Transient overexpression lysate of transforming, acidic coiled-coil containing protein 3 (TACC3) (as WB positive control) 100 ug
$436.00

file-alt Citations

A Highly Potent TACC3 Inhibitor as a Novel Anti-cancer Drug Candidate
Akbulut, Lengerli, Saatci et al
Mol. Cancer Ther. (2020)
AI Summary: OriGene’s purified TACC3 recombinant protein (TP310754) was used to validate the direct interaction between the novel inhibitor BO-264 and TACC3 through isothermal titration calorimetry in this study.
Snippet: blot analysis. 149 Isothermal titration calorimetry (ITC) 150 Purified TACC3 recombinant protein (TP310754;Origene, MD, USA) and BO-264 were prepared in 151 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol solution. BO-264 was loaded and titrated 152;- blot analysis. 149 Isothermal titration calorimetry (ITC) 150 Purified TACC3 recombinant protein (TP310754
Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function
Gulluni, Martini, De Santis et al
Cancer Cell (2017) 32 (4), 444-459.e7 DOI: 10.1016/j.ccell.2017.09.002
AI Summary: In this study, the OriGene PI3K-C2α antibody (Cat. # TA801690, 15H1) was used to investigate the scaffolding role of PI3K-C2α in mitotic spindle assembly and genomic stability in breast cancer cells.
Snippet: Proper organization of the mitotic spindle is key to genetic stability, but molecular components of inter-microtubule bridges that crosslink kinetochore fibers.;PI3K-C2 a OriGene Cat. # TA801690 15H1;RRID:AB_2626037 Acetylated-Tubulin monoclonal Sigma Cat. # 6-11B-1;RRID:AB_142598
Showing 1-2 of 2 papers.
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