HE4 (WFDC2) (NM_006103) Human Recombinant Protein
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 10 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_006094 |
| Locus ID | 10406 |
| UniProt ID | Q14508 |
| Cytogenetics | 20q13.12 |
| RefSeq Size | 570 |
| RefSeq ORF | 372 |
| Synonyms | dJ461P17.6; EDDM4; HE4; WAP5 |
| Summary | This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. provided by RefSeq, Jul 2008 |
| Protein Categories | Intracellular Proteins, Secreated Proteins |
| Protein Families | Secreted Protein, Transmembrane |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "HE4" proteins (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH308491 | WFDC2 MS Standard C13 and N15-labeled recombinant protein (NP_006094) | 10 ug |
$3,360.00
|
|
| LC416866 | Lyophilized WFDC2 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY416866 | Transient overexpression lysate of WAP four-disulfide core domain 2 (WFDC2) (as WB positive control) | 100 ug |
$436.00
|
|
| TP750124 | Purified recombinant protein of Human WAP four-disulfide core domain 2 (HE4), N-terminal Trx-HIS tag, expressed in E. coli, 50ug | 50 ug |
$270.00
|
|
Citations
HE4 expression is associated with hormonal elements and mediated by importin-dependent nuclear translocation
Lokich, Singh, Han et al
Sci Rep (2014) 4, 5500 DOI: 10.1038/srep05500
Lokich, Singh, Han et al
Sci Rep (2014) 4, 5500 DOI: 10.1038/srep05500
Cited by 52
AI Summary: OriGene products contributed to this study by providing the HE4 overexpression plasmid (RC204307) and HE4 shRNA (TL313573), which were used to manipulate HE4 expression levels and investigate its role in hormone response and nuclear translocation in ovarian cancer cells.
Snippet: Human epididymis protein 4 (HE4) is overexpressed in EOC and appears to have a role in ovarian cancer tumorigenesis. Little is known about the biologic function of the WFCD2 gene or its gene product HE4. However, there are hormonal responsive elements present within the WFCD2 promoter and we therefore hypothesized that steroid hormones could influence expression of HE4 in ovarian cancer
Showing 1-1 of 1 papers.
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