GCLC (NM_001498) Human Recombinant Protein
SKU
TP307915
Recombinant protein of human glutamate-cysteine ligase, catalytic subunit (GCLC), 20 µg
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 72.6 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_001489 |
| Locus ID | 2729 |
| UniProt ID | P48506 |
| Cytogenetics | 6p12.1 |
| RefSeq Size | 3823 |
| RefSeq ORF | 1911 |
| Synonyms | GCL; GCS; GLCL; GLCLC |
| Summary | Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.provided by RefSeq, Oct 2010 |
| Protein Categories | Cardiovascular diseases, Enzyme: Ligase, Growth Factors, Intracellular Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Glutathione metabolism, Metabolic pathways |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "GCLC" proteins (5)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH307915 | GCLC MS Standard C13 and N15-labeled recombinant protein (NP_001489) | 10 ug |
$3,360.00
|
|
| LC419901 | Lyophilized GCLC HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC434329 | Lyophilized GCLC HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY419901 | Transient overexpression lysate of glutamate-cysteine ligase, catalytic subunit (GCLC) (as WB positive control) | 100 ug |
$436.00
|
|
| LY434329 | Transient overexpression lysate of glutamate-cysteine ligase, catalytic subunit (GCLC), transcript variant 2 (as WB positive control) | 100 ug |
$436.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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