Nrf2 (NFE2L2) (NM_006164) Human Recombinant Protein
SKU
TP304140M
Recombinant protein of human nuclear factor (erythroid-derived 2)-like 2 (NFE2L2), transcript variant 1, 100 µg
$2,950.00
5 Days*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 67.6 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_006155 |
| Locus ID | 4780 |
| UniProt ID | Q16236 |
| Cytogenetics | 2q31.2 |
| RefSeq Size | 2859 |
| RefSeq ORF | 1815 |
| Synonyms | HEBP1; IMDDHH; Nrf-2; NRF2 |
| Summary | This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. provided by RefSeq, Sep 2015 |
| Protein Categories | Cancer: Gastrointestinal, Intracellular Proteins, Transciption Factors |
| Protein Families | Transcription Factors |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Citations
The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase
Sanghvi, Leibold, Mina et al
Cell (2019) 178 (4), 807-819.e21 DOI: 10.1016/j.cell.2019.07.031
Sanghvi, Leibold, Mina et al
Cell (2019) 178 (4), 807-819.e21 DOI: 10.1016/j.cell.2019.07.031
AI Summary: OriGene’s recombinant human NRF2 protein (Cat#TP760529) was used in this study to investigate the dependence of NRF2 activity on FN3K-mediated de-glycation, enabling key experiments on NRF2 glycation, stability, and function.
Snippet: Recombinant human NRF2 Origene Cat#TP760529 Erlotinib Selleck Chemicals Cat#S1023 MG-132 Sigma-Aldrich Cat#M7449 Trametinib Selleck Chemicals Cat#S2673 NAC Sigma-Aldrich Cat#A7250 BSO Sigma-Aldrich Cat#B2640 Ganciclovir Sigma-Aldrich Cat#G2536 Critical Commercial Assays
Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2
Pi, Bai, Reece et al
Free Radic Biol Med (2007) 42 (12), 1797-806 DOI: 10.1016/j.freeradbiomed.2007.03.001
Pi, Bai, Reece et al
Free Radic Biol Med (2007) 42 (12), 1797-806 DOI: 10.1016/j.freeradbiomed.2007.03.001
Cited by 213
AI Summary: In this paper, OriGene's anti-Nrf2 antibody (TA324872) was used to detect and analyze the phosphorylated forms of endogenous human Nrf2 by immunoblotting, contributing to the study of Nrf2 activation and degradation mechanisms.
Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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