TMS1(PYCARD) (NM_145183) Human Recombinant Protein

CAT#: TP302409

Recombinant protein of human PYD and CARD domain containing (PYCARD), transcript variant 3

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 Product Datasheet for 'TP302409'

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Size
    • 20 ug

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Specifications

Product Data
Description Recombinant protein of human PYD and CARD domain containing (PYCARD), transcript variant 3
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence Recombinant protein was produced with TrueORF clone, RC202409. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag C-MYC/DDK
Predicted MW 15.5
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Reference Data
RefSeq NP_660184
Locus ID 29108
Refseq Size 763
Cytogenetics 16p11.2
Refseq ORF 405
Synonyms ASC, TMS1, CARD5, MGC10332;ASC; CARD5; MGC10332; TMS; TMS-1; TMS1; apoptosis-associated speck-like protein containing a CARD; caspase recruitment domain protein 5; target of methylation-induced silencing-1; PYD and CARD domain containing
Summary This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Protein Families
Protein Pathways
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