ABI2 (NM_005759) Human Recombinant Protein
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 52.3 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_005750 |
| Locus ID | 10152 |
| UniProt ID | Q9NYB9 |
| Cytogenetics | 2q33.2 |
| RefSeq Size | 6533 |
| RefSeq ORF | 1425 |
| Synonyms | ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1; argBPIA; argBPIB; SSH3BP2 |
| Summary | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:7590236, PubMed:8649853, PubMed:10498863). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692).UniProtKB/Swiss-Prot Function |
| Protein Categories | Intracellular Proteins |
| Protein Pathways | Regulation of actin cytoskeleton |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "ABI2" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH300637 | ABI2 MS Standard C13 and N15-labeled recombinant protein (NP_005750) | 10 ug |
$3,360.00
|
|
| LC401755 | Lyophilized ABI2 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY401755 | Transient overexpression lysate of abl-interactor 2 (ABI2) (as WB positive control) | 100 ug |
$436.00
|
|
Citations
PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion
Jensen, Clements, Liou et al
J Cell Biol (2023) 222 (6) DOI: 10.1083/jcb.202208136
Jensen, Clements, Liou et al
J Cell Biol (2023) 222 (6) DOI: 10.1083/jcb.202208136
Cited by 16
AI Summary: OriGene’s recombinant ABI2 protein (Cat# TP300637) was used in this study to investigate the phosphorylation of ABI2 by PIM1, helping to elucidate the molecular mechanism by which PIM1 regulates actin dynamics and tumor cell invasion.
Snippet: # 97064-724), and doxycycline was purchased from Sigma-Aldrich (Cat# D9891-5G). Recombinant myelin basic protein (MBP) was a gift from Dr. Greg Rogers, and recombinant ABI2 protein was purchased from Origene (Cat# TP300637). Radio-labeled ATP was purchased from Perkin Elmer (Cat# BLU502A). The antibody to ABI2 was purchased from Bethyl Laboratories (Cat# A302-499A-M). GFP (Cat# 2956S), HA (Cat# 37
Showing 1-1 of 1 papers.
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