DDX58 Human Recombinant Protein

SKU TP701134

Purified recombinant protein of DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (DDX58), full length, 20ug

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence from TrueORF clone, [RC217615], encoding the full-length of DDX58
• Tag: C-DDK-His
• Predicted MW: 106.4 kDa
• Concentration: >0.05 ug/ul as determined by microplate Bradford method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 100 mM KCl, 6 mM MgCl2, 1 mM DTT, 10mM HEPES pH7.0 (+ 330 ug/ml Flag peptide),50% glycerine
• Note: For culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for at least 12 months from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Shipping: Dry Ice

Reference Data

• RefSeq: NP_055129.2
• Locus ID: 23586
• UniProt ID: O95786
• Cytogenetics: 9p21.1
• RefSeq Size: 4372
• RefSeq ORF: 2775
• Synonyms: RIG-I; RIG1; RIGI; RLR-1; SGMRT2
• Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of the antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2. [provided by RefSeq, Aug 2020]
• Protein Pathways: Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway