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Leptin (LEP) (NM_000230) Human Mass Spec Standard

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SKU
PH309259
LEP MS Standard C13 and N15-labeled recombinant protein (NP_000221)
Size:
10 ug
  $3,360.00
3 Weeks*
Bulk/Customize

Frequently Bought Together (1)

LY400087 Transient overexpression lysate of leptin (LEP) (as WB positive control) 100 ug
$436.00

Other products for "Leptin or NM_000230"

Specifications
Specifications
Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC209259
Predicted MW 18.6 kDa
Protein Sequence
Protein Sequence
>RC209259 protein sequence
Red=Cloning site Green=Tags(s)

MHWGTLCGFLWLWPYLFYVQAVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGLDFIPGLHPIL
TLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLPWASGLETLDSLGGVLEASGY
STEVVALSRLQGSLQDMLWQLDLSPGC

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_000221
RefSeq Size 3444
RefSeq ORF 501
Synonyms LEPD; OB; OBS
Locus ID 3952
UniProt ID P41159
Cytogenetics 7q32.1
Summary This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain, which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis, reproduction, bone formation and wound healing. Mutations in this gene and its regulatory regions cause severe obesity and morbid obesity with hypogonadism in human patients. A mutation in this gene has also been linked to type 2 diabetes mellitus development. provided by RefSeq, Aug 2017
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Adipocytokine signaling pathway, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Neuroactive ligand-receptor interaction
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Other "Leptin" proteins (4)
SKU Description Size Price
LC400087 Lyophilized LEP HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY400087 Transient overexpression lysate of leptin (LEP) (as WB positive control) 100 ug
$436.00
TP309259 Recombinant protein of human leptin (LEP), 20 µg 20 ug
$737.00
TP720054 Recombinant protein of human leptin (LEP) 10 ug
$150.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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