CDC25A (NM_001789) Human Mass Spec Standard
$3,360.00
3 Weeks*
Specifications
| Product Data | |
| Tag | C-Myc/DDK |
|---|---|
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | RC200496 |
| Predicted MW | 59.1 kDa |
| Protein Sequence | |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Labeling Method | Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| Storage | Store at -80°C. Avoid repeated freeze-thaw cycles. |
| Stability | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_001780 |
| RefSeq Size | 3717 |
| RefSeq ORF | 1572 |
| Synonyms | CDC25A2 |
| Locus ID | 993 |
| UniProt ID | P30304 |
| Cytogenetics | 3p21.31 |
| Summary | CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jul 2008 |
| Protein Families | Druggable Genome, Phosphatase |
| Protein Pathways | Cell cycle, Progesterone-mediated oocyte maturation |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "CDC25A" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| LC419746 | Lyophilized CDC25A HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY419746 | Transient overexpression lysate of cell division cycle 25 homolog A (S. pombe) (CDC25A), transcript variant 1 (as WB positive control) | 100 ug |
$436.00
|
|
| TP300496 | Recombinant protein of human cell division cycle 25 homolog A (S. pombe) (CDC25A), transcript variant 1, 20 µg | 20 ug |
$867.00
|
|
Citations
CDC25A protein stability represents a previously unrecognized target of HER2 signaling in human breast cancer: implication for a potential clinical relevance in trastuzumab treatment
Brunetto, Ferrara, Rampoldi et al
Neoplasia (2013) 15 (6), 579-90
Brunetto, Ferrara, Rampoldi et al
Neoplasia (2013) 15 (6), 579-90
AI Summary: OriGene’s pCMV6-AC-CDC25A-GFP vector was used for transient transfection to express the full-length human CDC25A protein, enabling the study of CDC25A’s role and regulation in HER2-positive breast cancer cells.
Snippet: Nikon Instruments SpA, Florence, Italy) with both a single-pass (green and orange) and a triple-pass filter band [4′,6 ... Transient transfections were performed using the pCMV6-AC-CDC25A- GFP vector (OriGene, Rockville, MD) expressing the full-coding sequence of human
Showing 1-1 of 1 papers.
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