PLCL1 (NM_006226) Human Tagged ORF Clone Lentiviral Particle

SKU RC229409L3V

Lenti ORF particles, PLCL1 (Myc-DDK-tagged)-Human phospholipase C-like 1 (PLCL1), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: PLCL1
• Synonyms: PLCE; PLCL; PLDL1; PPP1R127; PRIP
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC229409).
• ACCN: NM_006226
• ORF Size: 3285 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_006226.3
• RefSeq ORF: 3288 bp
• Locus ID: 5334
• UniProt ID: Q15111
• Cytogenetics: 2q33.1
• Domains: C2, PH, PI-PLC-X, PI-PLC-Y
• Protein Families: Druggable Genome
• MW: 122.5 kDa
• Summary: Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.[UniProtKB/Swiss-Prot Function]