Osteocalcin (BGLAP) (NM_199173) Human Tagged ORF Clone Lentiviral Particle

SKU RC220555L4V

Lenti ORF particles, BGLAP (mGFP-tagged) - Human bone gamma-carboxyglutamate (gla) protein (BGLAP), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: Osteocalcin
• Synonyms: BGP; OC; OCN
• Vector: pLenti-C-mGFP-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC220555).
• ACCN: NM_199173
• ORF Size: 300 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_199173.2
• RefSeq Size: 498 bp
• RefSeq ORF: 303 bp
• Locus ID: 632
• UniProt ID: P02818
• Cytogenetics: 1q22
• Protein Families: ES Cell Differentiation/IPS, Secreted Protein
• MW: 8.7 kDa
• Summary: This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]