Acid sphingomyelinase (SMPD1) (NM_000543) Human Tagged ORF Clone Lentiviral Particle

SKU RC219758L3V

Lenti ORF particles, SMPD1 (Myc-DDK tagged) - Human sphingomyelin phosphodiesterase 1, acid lysosomal (SMPD1), transcript variant 1, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: Acid sphingomyelinase
• Synonyms: ASM; ASMASE; NPD
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC219758).
• ACCN: NM_000543
• ORF Size: 1893 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_000543.3
• RefSeq Size: 2473 bp
• RefSeq ORF: 1896 bp
• Locus ID: 6609
• UniProt ID: P17405
• Cytogenetics: 11p15.4
• Domains: Metallophos, SAPB
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Lysosome, Metabolic pathways, Sphingolipid metabolism
• MW: 69.94 kDa
• Summary: The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010]