LNK (SH2B3) (NM_005475) Human Tagged ORF Clone Lentiviral Particle

SKU RC218359L3V

Lenti ORF particles, SH2B3 (Myc-DDK tagged) - Human SH2B adaptor protein 3 (SH2B3), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: LNK
• Synonyms: IDDM20; LNK
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC218359).
• ACCN: NM_005475
• ORF Size: 1725 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_005475.1
• RefSeq Size: 5423 bp
• RefSeq ORF: 1728 bp
• Locus ID: 10019
• UniProt ID: Q9UQQ2
• Cytogenetics: 12q24.12
• Domains: PH, SH2
• Protein Pathways: Neurotrophin signaling pathway
• MW: 63 kDa
• Summary: This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]