Nephrin (NPHS1) (NM_004646) Human Tagged ORF Clone Lentiviral Particle

SKU RC217677L4V

Lenti ORF particles, NPHS1 (mGFP-tagged) - Human nephrosis 1, congenital, Finnish type (nephrin) (NPHS1), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: Nephrin
• Synonyms: CNF; nephrin; NPHN
• Vector: pLenti-C-mGFP-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC217677).
• ACCN: NM_004646
• ORF Size: 3723 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_004646.1
• RefSeq Size: 4285 bp
• RefSeq ORF: 3726 bp
• Locus ID: 4868
• UniProt ID: O60500
• Cytogenetics: 19q13.12
• Protein Families: Druggable Genome, Transmembrane
• MW: 134.6 kDa
• Summary: This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.[provided by RefSeq, Oct 2009]