ARHGEF9 (NM_015185) Human Tagged ORF Clone Lentiviral Particle

SKU RC216681L2V

Lenti ORF particles, ARHGEF9 (mGFP-tagged) - Human Cdc42 guanine nucleotide exchange factor (GEF) 9 (ARHGEF9), transcript variant 1, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: ARHGEF9
• Synonyms: COLLYBISTIN; DEE8; EIEE8; HPEM-2; PEM-2; PEM2
• Vector: pLenti-C-mGFP
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC216681).
• ACCN: NM_015185
• ORF Size: 1548 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_015185.1
• RefSeq Size: 5413 bp
• RefSeq ORF: 1551 bp
• Locus ID: 23229
• UniProt ID: O43307
• Cytogenetics: Xq11.1
• Domains: PH, RhoGEF, SH3
• MW: 60.8 kDa
• Summary: The protein encoded by this gene is a Rho-like GTPase that switches between the active (GTP-bound) state and inactive (GDP-bound) state to regulate CDC42 and other genes. This brain-specific protein also acts as an adaptor protein for the recruitment of gephyrin and together these proteins facilitate receceptor recruitement in GABAnergic and glycinergic synapses. Defects in this gene are the cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy, as well as several other types of cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]