RASGRP1 (NM_005739) Human Tagged ORF Clone Lentiviral Particle

SKU RC212473L4V

Lenti ORF particles, RASGRP1 (mGFP-tagged) - Human RAS guanyl releasing protein 1 (calcium and DAG-regulated) (RASGRP1), transcript variant 1, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: RASGRP1
• Synonyms: CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP
• Vector: pLenti-C-mGFP-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC212473).
• ACCN: NM_005739
• ORF Size: 2391 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_005739.2
• RefSeq Size: 5048 bp
• RefSeq ORF: 2394 bp
• Locus ID: 10125
• UniProt ID: O95267
• Cytogenetics: 15q14
• Domains: DAG_PE-bind, EFh, RasGEF, RasGEFN
• Protein Pathways: MAPK signaling pathway, T cell receptor signaling pathway
• MW: 90.4 kDa
• Summary: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]