p57 Kip2 (CDKN1C) (NM_000076) Human Tagged ORF Clone Lentiviral Particle

SKU RC209840L3V

Lenti ORF particles, CDKN1C (Myc-DDK-tagged)-Human cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 1, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: p57 Kip2
• Synonyms: BWCR; BWS; KIP2; p57; p57Kip2; WBS
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC209840).
• ACCN: NM_000076
• ORF Size: 936 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_000076.1
• RefSeq Size: 1511 bp
• RefSeq ORF: 951 bp
• Locus ID: 1028
• UniProt ID: P49918
• Cytogenetics: 11p15.4
• Domains: CDI
• Protein Families: Druggable Genome
• Protein Pathways: Cell cycle
• MW: 31.8 kDa
• Summary: This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]