Cytokeratin 8 (KRT8) (NM_002273) Human Tagged ORF Clone Lentiviral Particle

SKU RC209570L4V

Lenti ORF particles, KRT8 (mGFP-tagged) - Human keratin 8 (KRT8), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: Cytokeratin 8
• Synonyms: CARD2; CK-8; CK8; CYK8; K2C8; K8; KO
• Vector: pLenti-C-mGFP-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC209570).
• ACCN: NM_002273
• ORF Size: 1449 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_002273.2
• RefSeq Size: 1788 bp
• RefSeq ORF: 1452 bp
• Locus ID: 3856
• UniProt ID: P05787
• Cytogenetics: 12q13.13
• Domains: filament
• Protein Families: Druggable Genome
• MW: 53.5 kDa
• Summary: This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]