Translation factor GUF1, mitochondrial (GUF1) (NM_021927) Human Tagged ORF Clone Lentiviral Particle

SKU RC207735L4V

Lenti ORF particles, GUF1 (mGFP-tagged) - Human GUF1 GTPase homolog (S. cerevisiae) (GUF1), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: Translation factor GUF1, mitochondrial
• Synonyms: DEE40; EF-4; EF4; EIEE40
• Vector: pLenti-C-mGFP-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC207735).
• ACCN: NM_021927
• ORF Size: 2007 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_021927.1
• RefSeq Size: 4230 bp
• RefSeq ORF: 2010 bp
• Locus ID: 60558
• UniProt ID: Q8N442
• Cytogenetics: 4p12
• Domains: EFG_C, GTP_EFTU, GTP_EFTU_D2
• MW: 74.3 kDa
• Summary: This gene encodes a GTPase that triggers back-translocation of the elongating ribosome during mitochondrial protein synthesis. The protein contains a highly conserved C-terminal domain not found in other GTPases that facilitates tRNA binding. The encoded protein is thought to prevent misincorporation of amino acids in stressful, suboptimal conditions. An allelic variant in this gene has been associated with early infantile epileptic encephalopathy-40. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]