FHIT (NM_002012) Human Tagged ORF Clone Lentiviral Particle

SKU RC207120L3V

Lenti ORF particles, FHIT (Myc-DDK tagged) - Human fragile histidine triad gene (FHIT), transcript variant 1, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: FHIT
• Synonyms: AP3Aase; FRA3B
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC207120).
• ACCN: NM_002012
• ORF Size: 441 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_002012.1
• RefSeq Size: 1103 bp
• RefSeq ORF: 444 bp
• Locus ID: 2272
• UniProt ID: P49789
• Cytogenetics: 3p14.2
• Domains: HIT
• Protein Pathways: Non-small cell lung cancer, Purine metabolism, Small cell lung cancer
• MW: 16.9 kDa
• Summary: The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]