MARCH8 (MARCHF8) (NM_001002266) Human Tagged ORF Clone Lentiviral Particle

SKU RC205477L3V

Lenti ORF particles, MARCH8 (Myc-DDK tagged) - Human membrane-associated ring finger (C3HC4) 8 (MARCH8), transcript variant 3, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: MARCHF8
• Synonyms: c-MIR; CMIR; MARCH-VIII; MARCH8; MIR; RNF178
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC205477).
• ACCN: NM_001002266
• ORF Size: 873 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_001002266.1
• RefSeq Size: 4812 bp
• RefSeq ORF: 876 bp
• Locus ID: 220972
• UniProt ID: Q5T0T0
• Cytogenetics: 10q11.21-q11.22
• Protein Families: Druggable Genome, Transmembrane
• MW: 32.9 kDa
• Summary: MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]