KLHL2 (NM_007246) Human Tagged ORF Clone Lentiviral Particle

SKU RC205347L3V

Lenti ORF particles, KLHL2 (Myc-DDK tagged) - Human kelch-like 2, Mayven (Drosophila) (KLHL2), transcript variant 1, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: KLHL2
• Synonyms: ABP-KELCH; MAV; MAYVEN
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC205347).
• ACCN: NM_007246
• ORF Size: 1779 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_007246.2, NP_009177.2
• RefSeq Size: 3137 bp
• RefSeq ORF: 1782 bp
• Locus ID: 11275
• UniProt ID: O95198
• Cytogenetics: 4q32.3
• Domains: BTB, Kelch
• MW: 66.1 kDa
• Summary: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.[UniProtKB/Swiss-Prot Function]